SDN-AAA: Towards the standard management of AAA infrastructures

Software Defined Networking (SDN) is a widely deployed technology enabling the agile and flexible management of networks and services. This paradigm represents an appropriate candidate to address the dynamic and secure management of large and complex Authentication, Authorization and Accounting (AAA) infrastructures. In those infrastructures, there are several nodes which must exchange information securely to interconnect different realms. This article describes a novel SDN-based framework with a data model-driven approach following the standard YANG, named SDN-AAA, which can be used to dynamically manage routing and security configuration in AAA scenarios.Comment: 7 pages, 5 figure

Fuzzy association rules for biological data analysis: A case study on yeast

<p>Abstract</p> <p>Background</p> <p>Last years' mapping of diverse genomes has generated huge amounts of biological data which are currently dispersed through many databases. Integration of the information available in the various databases is required to unveil possible associations relating already known data. Biological data are often imprecise and noisy. Fuzzy set theory is specially suitable to model imprecise data while association rules are very appropriate to integrate heterogeneous data.</p> <p>Results</p> <p>In this work we propose a novel fuzzy methodology based on a fuzzy association rule mining method for biological knowledge extraction. We apply this methodology over a yeast genome dataset containing heterogeneous information regarding structural and functional genome features. A number of association rules have been found, many of them agreeing with previous research in the area. In addition, a comparison between crisp and fuzzy results proves the fuzzy associations to be more reliable than crisp ones.</p> <p>Conclusion</p> <p>An integrative approach as the one carried out in this work can unveil significant knowledge which is currently hidden and dispersed through the existing biological databases. It is shown that fuzzy association rules can model this knowledge in an intuitive way by using linguistic labels and few easy-understandable parameters.</p

Ehmi: Review and guidelines for deployment on autonomous vehicles

Human-machine interaction is an active area of research due to the rapid development of autonomous systems and the need for communication. This review provides further insight into the specific issue of the information flow between pedestrians and automated vehicles by evaluating recent advances in external human-machine interfaces (eHMI), which enable the transmission of state and intent information from the vehicle to the rest of the traffic participants. Recent developments will be explored and studies analyzing their effectiveness based on pedestrian feedback data will be presented and contextualized. As a result, we aim to draw a broad perspective on the current status and recent techniques for eHMI and some guidelines that will encourage future research and development of these systems

ITQ-39 zeolite, an efficient catalyst for the conversion of low value naphtha fractions into diesel fuel: The role of pore size on molecular diffusion and reactivity

[EN] ITQ-39, a multipore zeolite with interconnected 12- and 10-ring channel systems, effectively catalyzes the alkylation of two low value naphtha fractions for the production of diesel range alkylaromatics. A catalytic and molecular dynamics study allows us to conclude that its higher selectivity to the desired diesel fraction and, especially, its longer catalyst life as compared to beta or MCM-22, conventionally used as heterogeneous alkylation catalysts, are due to the combined contribution of its small nano-sized crystallites, moderate Bronsted acidity and unique framework topology. The small diffusion coefficients obtained for alkylaromatics on ITQ-39 as compared to those corresponding to the large pore beta zeolite evidence the significant diffusional problems of most of the reactants and products through the channels of the ITQ-39 structure. Thus, alkylation reactions on this zeolite seem to occur mainly on the most external acid sites (external surface, pore mouths), whereas the zeolite structure contributes positively by preventing undesired reactions to occur, which would result in lower selectivity to the monoalkylated products and in a faster catalyst deactivation.Financial support by the Spanish Government-MINECO through "Severo Ochoa" (SEV 2012-0267), Consolider Ingenio 2010-Multicat, MAT2012-37160 and MAT2012-31657, by the European Union through ERC-AdG-2014-671093 - SynCatMatch and by the Generalitat Valenciana through the Prometeo program (PROME-TEOII/2013/011) is acknowledged. Repsol is thanked for financial support and permission to publish these results. G.S. thanks ASIC-UPV for computing time. The Electron Microscopy Service of the UPV is acknowledged for their help in samples characterization.Martínez Armero, ME.; Moliner Marin, M.; Sastre Navarro, GI.; Rey Garcia, F.; Martínez, C.; Corma Canós, A. (2016). ITQ-39 zeolite, an efficient catalyst for the conversion of low value naphtha fractions into diesel fuel: The role of pore size on molecular diffusion and reactivity. Journal of Catalysis. 333:127-138. https://doi.org/10.1016/j.jcat.2015.10.024S12713833

Aloinjerto como material de relleno de defecto óseo metafisario en las fracturas de platillo tibial

El propósito de este estudio fue valorar la eficacia del aloinjerto en las fracturas de platillo tibial como material de relleno para los defectos metafisarios, así como una alternativa que disminuya la morbilidad (dolor en el lugar de la extracción, infección del mismo, alargamiento del tiempo de intervención quirúrgica...) sin que disminuya la capacidad de integración ósea y se comprometa la realización de una movilización precoz. Para ello se han revisado trece casos clínicos en los que se ha practicado una reducción anatómica, fijación interna y relleno con aloinjerto procedente del Banco de Huesos, apreciándose una integración ósea del mismo en el plazo aproximado de 10 semanas. Valorando los resultados con arreglo a los criterios de Honkonen hemos obtenido 7 casos con excelente resultado, 4 casos con bueno y 2 casos con mal resultado. Consideramos que el aloinjerto óseo es una eficaz alternativa en el relleno de los defectos metafisarios óseos asociados a las fracturas de platillo tibial.The purpose of this study was to assess the efficacy of allograft bone as filling agent of metaphyseal defects in tibial plateau fractures, trying to find an effective alternative to decrease the morbility (donor site complications: painful, infection, increased surgical time...), without affecting bone ingrowth and early motion. A total of 13 cases treated by anatomic open reduction, rigid internal fixation and filling with frozen allograft bone have been reviewed. When evaluating results according to Honkonen, excellent results were found in 7 cases, good results in 4 and bad results in 2. Allograft bone seems to be an effective alternative for repairing metaphyseal defects associated with tibial plateau fractures

Synthesis design and structure of a multipore zeolite with interconnected 12- and 10-MR channels

[EN] A new molecular sieve, ITQ-38, containing interconnected large and medium pores in its structure has been synthesized. The rational combination of dicationic piperidine-derivative molecules as organic structure directing agents (OSDAs) with germanium and boron atoms in alkaline media has allowed the synthesis of ITQ-38 zeolite. High-resolution transmission electron microscopy (HRTEM) has been used to elucidate the framework topology of ITQ-38, revealing the presence of domains of perfect ITQ-38 crystals as well as very small areas containing nanosized ITQ-38/ITQ-22 intergrowths. The structure of ITQ-38 is highly related to ITQ-22 and the recently described polymorph C of ITQ-39 zeolite. It shares a common building layer with ITQ-22 and contains the same building unit as the polymorph C of ITQ-39. All three structures present similar framework density, 16.1 T atoms/1000 angstrom(3).Financial support by the Spanish MICINN (MAT2009-14528-C02-01 and MAT2006-14274-C02-01), Consolider Ingenio 2010-Multicat, Generalitat Valenciana by the PROMETEO program, UPV through PAJD-06-11 (n.1952), the Swedish Research Council (VR), the Swedish Governmental Agency for Innovation Systems (VINNOVA) and Goran Gustafsson Foundtion for Natural Sciences and Medical Research, is acknowledged. Manuel Moliner also acknowledges the "Subprograma Ramon y Cajal" for the contract RYC-2011-08972. Wei Wan was supported by a postdoctoral grant from the Carl-Trygger Foundation. The EM facility was supported by Knut and Alice Wallenberg Foundation. The authors thank the beamline BM01B at ESRF in Grenoble for beamtime allocation (exp. CH-2493). Gunnel Karlsson is kindly thanked for TEM sample preparation by ultramicrotomy. Dedicated to Prof. Miguel A. Miranda on his 60th Birthday.Moliner Marin, M.; Willhammar, T.; Wan, W.; González, J.; Rey Garcia, F.; Jorda Moret, JL.; Zou, X.... (2012). Synthesis design and structure of a multipore zeolite with interconnected 12- and 10-MR channels. Journal of the American Chemical Society. 134(14):6473-6478. https://doi.org/10.1021/ja301082nS647364781341

Unusually Low Heat of Adsorption of CO2 on AlPO and SAPO Molecular Sieves

[EN] The capture of CO2 from post-combustion streams or from other mixtures, such as natural gas, is an effective way of reducing CO2 emissions, which contribute to the greenhouse effect in the atmosphere. One of the developing technologies for this purpose is physisorption on selective solid adsorbents. The ideal adsorbents are selective toward CO2, have a large adsorption capacity at atmospheric pressure and are easily regenerated, resulting in high working capacity. Therefore, adsorbents combining molecular sieving properties and low heats of adsorption of CO2 are of clear interest as they will provide high selectivities and regenerabilities in CO2 separation process. Here we report that some aluminophosphate (AlPO) and silicoaluminophosphate (SAPO) materials with LTA, CHA and AFI structures present lower heats of adsorption of CO2 (13¿25 kJ/mol) than their structurally analogous zeolites at comparable framework charges. In some cases, their heats of adsorption are even lower than those of pure silica composition (20¿25 kJ/mol). This could mean a great improvement in the regeneration process compared to the most frequently used zeolitic adsorbents for this application while maintaining most of their adsorption capacity, if materials with the right stability and pore size and topology are found.We acknowledge the Spanish Ministry of Sciences, Innovation and Universities (MCIU), State Research Agency (AEI), and the European Fund for Regional Development (FEDER) for their funding via projects Multi2HYcat (EU-Horizon 2020 funded project under grant agreement no. 720783), Program Severo Ochoa SEV-2016-0683 and RTI2018-101033-B-I00 and also Fundacion Ramon Areces for funding through a research contract (CIVP18A3908). EP-B thanks the MCIU for his grant (FPU15/01602). NG-C thanks MCIU for her grant (BES-2016-078178).Pérez-Botella, E.; Martínez-Franco, R.; Gonzalez-Camuñas, N.; Cantin Sanz, A.; Palomino Roca, M.; Moliner Marin, M.; Valencia Valencia, S.... (2020). Unusually Low Heat of Adsorption of CO2 on AlPO and SAPO Molecular Sieves. Frontiers in Chemistry. 8:1-10. https://doi.org/10.3389/fchem.2020.588712S1108Bacsik, Z., Cheung, O., Vasiliev, P., & Hedin, N. (2016). Selective separation of CO2 and CH4 for biogas upgrading on zeolite NaKA and SAPO-56. Applied Energy, 162, 613-621. doi:10.1016/j.apenergy.2015.10.109BaerlocherC. H. McCuskerL. B. Database of Zeolite StructuresBoot-Handford, M. E., Abanades, J. C., Anthony, E. J., Blunt, M. J., Brandani, S., Mac Dowell, N., … Fennell, P. S. (2014). Carbon capture and storage update. Energy Environ. Sci., 7(1), 130-189. doi:10.1039/c3ee42350fBourgogneM. GuthJ.-L. WeyR. Process for the Preparation of Synthetic Zeolites, and Zeolites Obtained by Said Process1985Bui, M., Adjiman, C. S., Bardow, A., Anthony, E. J., Boston, A., Brown, S., … Mac Dowell, N. (2018). Carbon capture and storage (CCS): the way forward. Energy & Environmental Science, 11(5), 1062-1176. doi:10.1039/c7ee02342aCheung, O., Liu, Q., Bacsik, Z., & Hedin, N. (2012). Silicoaluminophosphates as CO2 sorbents. Microporous and Mesoporous Materials, 156, 90-96. doi:10.1016/j.micromeso.2012.02.003Corma, A., Rey, F., Rius, J., Sabater, M. J., & Valencia, S. (2004). Supramolecular self-assembled molecules as organic directing agent for synthesis of zeolites. Nature, 431(7006), 287-290. doi:10.1038/nature02909Dawson, D. M., Griffin, J. M., Seymour, V. R., Wheatley, P. S., Amri, M., Kurkiewicz, T., … Ashbrook, S. E. (2017). A Multinuclear NMR Study of Six Forms of AlPO-34: Structure and Motional Broadening. The Journal of Physical Chemistry C, 121(3), 1781-1793. doi:10.1021/acs.jpcc.6b11908Díaz-Cabañas, M.-J., & Barrett, P. A. (1998). 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(2008). Reversible Chemisorbents for Carbon Dioxide and Their Potential Applications. Industrial & Engineering Chemistry Research, 47(21), 8048-8062. doi:10.1021/ie800795yLee, S.-Y., & Park, S.-J. (2015). A review on solid adsorbents for carbon dioxide capture. Journal of Industrial and Engineering Chemistry, 23, 1-11. doi:10.1016/j.jiec.2014.09.001Lemishko, T., Valencia, S., Rey, F., Jiménez-Ruiz, M., & Sastre, G. (2016). Inelastic Neutron Scattering Study on the Location of Brønsted Acid Sites in High Silica LTA Zeolite. The Journal of Physical Chemistry C, 120(43), 24904-24909. doi:10.1021/acs.jpcc.6b09012Leung, D. Y. C., Caramanna, G., & Maroto-Valer, M. M. (2014). An overview of current status of carbon dioxide capture and storage technologies. Renewable and Sustainable Energy Reviews, 39, 426-443. doi:10.1016/j.rser.2014.07.093Liu, X., Vlugt, T. J. H., & Bardow, A. (2011). Maxwell–Stefan diffusivities in liquid mixtures: Using molecular dynamics for testing model predictions. Fluid Phase Equilibria, 301(1), 110-117. doi:10.1016/j.fluid.2010.11.019Man, P. P., Briend, M., Peltre, M. J., Lamy, A., Beaunier, P., & Barthomeuf, D. (1991). A topological model for the silicon incorporation in SAPO-37 molecular sieves: Correlations with acidity and catalysis. Zeolites, 11(6), 563-572. doi:10.1016/s0144-2449(05)80006-5Martin, C., Tosi-Pellenq, N., Patarin, J., & Coulomb, J. P. (1998). Sorption Properties of AlPO4-5 and SAPO-5 Zeolite-like Materials. Langmuir, 14(7), 1774-1778. doi:10.1021/la960755cMartínez-Franco, R., Cantín, Á., Vidal-Moya, A., Moliner, M., & Corma, A. (2015). Self-Assembled Aromatic Molecules as Efficient Organic Structure Directing Agents to Synthesize the Silicoaluminophosphate SAPO-42 with Isolated Si Species. Chemistry of Materials, 27(8), 2981-2989. doi:10.1021/acs.chemmater.5b00337Martínez-Franco, R., Li, Z., Martínez-Triguero, J., Moliner, M., & Corma, A. (2016). Improving the catalytic performance of SAPO-18 for the methanol-to-olefins (MTO) reaction by controlling the Si distribution and crystal size. Catalysis Science & Technology, 6(8), 2796-2806. doi:10.1039/c5cy02298cMiyamoto, M., Fujioka, Y., & Yogo, K. (2012). Pure silica CHA type zeolite for CO2 separation using pressure swing adsorption at high pressure. Journal of Materials Chemistry, 22(38), 20186. doi:10.1039/c2jm34597hVan Nordstrand, R. A., Santilli, D. S., & Zones, S. I. (1988). An All-Silica Molecular Sieve That Is Isostructural with AlPO4-5. Perspectives in Molecular Sieve Science, 236-245. doi:10.1021/bk-1988-0368.ch015Palomino, M., Corma, A., Rey, F., & Valencia, S. (2009). New Insights on CO2−Methane Separation Using LTA Zeolites with Different Si/Al Ratios and a First Comparison with MOFs. Langmuir, 26(3), 1910-1917. doi:10.1021/la9026656Pham, T. D., Hudson, M. R., Brown, C. M., & Lobo, R. F. (2014). 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Measurement of urea and creatinine in saliva of dogs : a pilot study

Urea and creatinine in saliva have been reported to be possible markers of chronic kidney disease (CKD) in humans. The aim of this study was to assess if urea and creatinine could be measured in canine saliva, and to evaluate their possible changes in situations of CKD

Psychological Effects of a 1-Month Meditation Retreat on Experienced Meditators: The Role of Non-attachment

Background: There are few studies devoted to assessing the impact of meditation-intensive retreats on the well-being, positive psychology, and personality of experienced meditators. We aimed to assess whether a 1-month Vipassana retreat: (a) would increase mindfulness and well-being; (b) would increase prosocial personality traits; and (c) whether psychological changes would be mediated and/or moderated by non-attachment. Method: A controlled, non-randomized, pre-post-intervention trial was used. The intervention group was a convenience sample (n = 19) of experienced meditators who participated in a 1-month Vipassana meditation retreat. The control group (n = 19) comprised matched experienced meditators who did not take part in the retreat. During the retreat, the mean duration of daily practice was 8-9 h, the diet was vegetarian and silence was compulsory. The Experiences Questionnaire (EQ), Non-attachment Scale (NAS), Positive and Negative Affect Schedule (PANAS), Satisfaction With Life Scale (SWLS), Temperament Character Inventory Revised (TCI-R-67), Five Facets Mindfulness Questionnaire (FFMQ), Self-Other Four Immeasurables (SOFI) and the MINDSENS Composite Index were administered. ANCOVAs and linear regression models were used to assess pre-post changes and mediation/moderation effects. Results: Compared to controls, retreatants showed increases in non-attachment, observing, MINDSENS, positive-affect, balance-affect, and cooperativeness; and decreases in describing, negative-others, reward-dependence and self-directedness. Non-attachment had a mediating role in decentring, acting aware, non-reactivity, negative-affect, balance-affect and self-directedness; and a moderating role in describing and positive others, with both mediating and moderating effects on satisfaction with life. Conclusions: A 1-month Vipassana meditation retreat seems to yield improvements in mindfulness, well-being, and personality, even in experienced meditators. Non-attachment might facilitate psychological improvements of meditation, making it possible to overcome possible ceiling effects ascribed to non-intensive practices

Avanços na Detecção Precoce e Tratamento de Câncer de Ovário: Uma análise dos métodos mais recentes de diagnóstico e abordagens terapêuticas

Ovarian cancer is one of the most significant challenges in oncology due to its frequently late diagnosis and high mortality rates. This review examines recent advances in the early detection and treatment of ovarian cancer, focusing on innovations in diagnostic methods and therapeutic approaches. In diagnosis, the emphasis is on the development of more precise biomarkers, advancements in imaging techniques, and the application of artificial intelligence to enhance early detection. In treatment, the emergence of targeted therapies, such as PARP inhibitors and immunotherapy, is highlighted, especially in patients with specific genetic profiles. The review also addresses the importance of personalized therapeutic strategies and discusses the challenges related to treatment resistance and access to therapeutic advances. It is concluded that, although there has been significant progress, there are still challenges to be overcome, including the need for greater accessibility and equality in the treatment and diagnosis of ovarian cancer.O câncer de ovário é um dos desafios mais significativos na oncologia devido ao seu diagnóstico frequentemente tardio e taxas elevadas de mortalidade. Esta revisão analisa os avanços recentes na detecção precoce e no tratamento do câncer de ovário, focando em inovações em métodos diagnósticos e abordagens terapêuticas. No diagnóstico, a ênfase recai sobre o desenvolvimento de biomarcadores mais precisos, avanços em técnicas de imagem e a aplicação da inteligência artificial para aprimorar a detecção precoce. No tratamento, destaca-se a emergência de terapias direcionadas, como inibidores de PARP e imunoterapia, especialmente em pacientes com perfis genéticos específicos. A revisão também aborda a importância de estratégias terapêuticas personalizadas e discute os desafios relacionados à resistência ao tratamento e acesso aos avanços terapêuticos. Conclui-se que, embora haja progressos significativos, ainda há desafios a serem superados, incluindo a necessidade de maior acessibilidade e igualdade no tratamento e diagnóstico do câncer de ovário